Table 3 Comparison of clinical characteristics of tubulointerstitial nephritis and uveitis with our patient
From: Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report
| Clinical characteristics† | Our patient |
|---|---|
| AIN in TINU | |
| 1. Abnormal renal function | Mild elevation of serum creatinine. AH treated with lifestyle interventions already before disease onset |
| 2. Abnormal urinalysis | |
| Low-grade proteinuria, glycosuria, urinary eosinophils, hematuria, sterile pyuria, and presence of white cell casts, as well as phosphaturia and aminoaciduria. Elevated urinary NAG, α-1 and β-2 microglobulin | Mild proteinuria, microalbuminuria, elevated α-1 microglobulin, normoglycemic glycosuria |
| 3. Systemic illness lasting ≥ 2 weeks | No history of systemic symptoms |
| (a) Signs and symptoms: fever, rash, weight loss, anorexia, malaise, fatigue, flank pain, arthralgia or myalgia | Marked elevation of ESR, mild elevation of CRP, mild anemia |
| (b) Blood and urinary findings: anemia, eosinophilia, elevated ESR and CRP, abnormal LFT, acid–base disorders | |
| Uveitis in TINU | |
| 1. Classical bilateral, anterior uveitis with ocular redness, pain, and photophobia | Unilateral anterior uveitis at presentation and contralateral anterior uveitis after 1 month |
| 2. Atypical uveitis: intermediate and/or posterior involvement | |
| 3. Complications: posterior synechiae, cystoid macular edema, disc edema, elevated intraocular pressure, cataract formation | |